Recent reports that show promise of practical clinical utility include the following:
The immortalizing enzyme, telomerase, has been linked to carcinogenesis and its confirmed presence in laryngeal
P.1728
cancer specimens may provide a novel molecular marker, especially for diagnosing persistent malignancy after radiation failure (1).
A form of hyaluronidase, PH-20, which is expressed in primary laryngeal cancer tissue, is elevated even more in metastatic lesions, such that it can serve as a useful tumor marker and have prognostic value (2).
Using polymerase chain reaction techniques, herpes simplex virus DNA was found in 75% of laryngeal cancers, but only in 25% of oral cancers and in no control biopsy tissue, suggesting that it may be a cocarcinogen in some patients (3).
Mutations of the p53 gene have been found to correlate with the clinical outcome of patients with laryngeal cancer. The predictive power of p53 gene mutations is an area of high research interest at this time (4).
Retinoblastoma protein expression negativity is associated with a higher likelihood of lymph node metastasis and a significantly lower 5-year survival rate (5).
Low levels of cyclin D1 can be detected by immunohistochemical staining of paraffin-embedded specimens.
Low levels of cyclin D1 correlate with radio-resistant early-stage larynx carcinoma (6).
Technorati Tags: telomerase, hyaluronidase
The immortalizing enzyme, telomerase, has been linked to carcinogenesis and its confirmed presence in laryngeal
P.1728
cancer specimens may provide a novel molecular marker, especially for diagnosing persistent malignancy after radiation failure (1).
A form of hyaluronidase, PH-20, which is expressed in primary laryngeal cancer tissue, is elevated even more in metastatic lesions, such that it can serve as a useful tumor marker and have prognostic value (2).
Using polymerase chain reaction techniques, herpes simplex virus DNA was found in 75% of laryngeal cancers, but only in 25% of oral cancers and in no control biopsy tissue, suggesting that it may be a cocarcinogen in some patients (3).
Mutations of the p53 gene have been found to correlate with the clinical outcome of patients with laryngeal cancer. The predictive power of p53 gene mutations is an area of high research interest at this time (4).
Retinoblastoma protein expression negativity is associated with a higher likelihood of lymph node metastasis and a significantly lower 5-year survival rate (5).
Low levels of cyclin D1 can be detected by immunohistochemical staining of paraffin-embedded specimens.
Low levels of cyclin D1 correlate with radio-resistant early-stage larynx carcinoma (6).
Technorati Tags: telomerase, hyaluronidase
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